GLP-1 weight loss Harley street London

We prescribe semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro) as part of a structured programme. These GLP-1 receptor agonists regulate appetite and improve satiety, making them powerful tools for sustained fat loss. All prescribing is carried out during consultations by a GP with over twenty years’ medical experience. Consultations are conducted in person and include taking blood pressure and waist circumference measurements alongside a full medical and lifestyle history.

This programme is suitable for adults with a BMI over 25 who are ready to approach weight loss in a medically responsible way. It is also suitable for patients who have already begun GLP-1 therapy elsewhere and are seeking better follow-up, in-person prescribing, or structural preservation. Regardless of background, all patients are assessed individually. We do not separate prescribing from clinical care.

Alongside their weight-loss effects by inhibiting appetite, GLP-1 receptor agonists also lead to reductions in lean body mass, including muscle and supportive fat pads, which can result in unintended effects: hollowing of the face, softening of the jawline, loss of core strength, or laxity in the neck and lower face. These changes are not cosmetic. They are physiological and entirely predictable. However, most clinics offer little in the way of prevention.

At Self London, we treat fat loss as a whole-body process. Our programme addresses both the internal mechanism and the structural consequences with oversight, continuity and discretion. We initiate treatment at low doses and build gradually, with regular review throughout this build-up process. Follow-up is structured, and side-effect management is built into the programme. Where needed, blood tests can also be carried out for monitoring and progress.

From the outset, we take steps to preserve structure. In our view, the best results come when GLP-1 prescribing, Sofwave skin-tightening and Pure Impact muscle toning are planned together from the beginning, not introduced later. Creating lift in the face and supporting dermal collagen and elastin before visible fat loss begins helps reduce depletion and maintain definition. Preserving or building muscle mass early, particularly in the glutes and core, helps protect strength, posture, and tone as body composition shifts. These treatments are considered at the initial consultation and built into the wider plan. This is not cosmetic enhancement. It is structural preparation and part of treating fat loss properly.

VISIA imaging may be used to track soft tissue changes or monitor skin quality over time. In some cases, we recommend regenerative therapies such as fractional laser or polynucleotides to improve hydration and density in areas where early collapse or thinning becomes visible. These treatments are introduced with care, guided by anatomy and timing rather than aesthetic trends.

In selected patients, we also offer a micro-dosing phase. This is an off-label maintenance approach, using lower or less frequent doses of medication to preserve effect once the primary goal is achieved. It is not a default option and is introduced only where appropriate, with consent and review.